The Nationwide Institute of Diabetes and Digestive and Kidney Illnesses lately awarded a group of UTHSC researchers $1.99 million for his or her work to advance understanding of the pathophysiology of prediabetes, diabetes, and associated issues. Sam Dagogo-Jack, MD, professor of Drugs and director of the Basic Scientific Analysis Heart, is a principal investigator, together with Nawajes Mandal, PhD, affiliate professor within the Departments of Ophthalmology, Anatomy and Neurobiology, and Pharmaceutical Sciences. Their venture is titled “Ceramides and Sphingolipids as Predictors of Incident Dysglycemia.”
Dr. Dagogo-Jack is a number one scientific researcher and an professional on diabetes and prediabetes. Dr. Mandal is a fundamental scientist and a number one professional on the function of bioactive lipid signlaing, like sphingolipids (SPLs) and ceramides, in human ocular, metabolic, neurodegeneration, and inflammatory illnesses. Utilizing their mixed professional views, the 2 hypothesize that ceramides and different SPLs are vital modulators affecting the development from regular glucose regulation, by way of prediabetes, to kind 2 diabetes and related diabetic issues.
To check this speculation, they’ll make the most of specimens from two research wherein Dr. Dagogo-Jack is the principal investigator: the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC), which concerned members with a traditional focus of glucose who had a parental historical past of kind 2 diabetes; and the Diabetes Prevention Program/Diabetes Prevention Program End result Research (DPP/DPPOS), which adopted members already recognized with prediabetes for the development of type 2 diabetes. Moreover, samples from 200 people with regular glucose concentrations and no household historical past of diabetes will function normative controls.
The venture will analyze, profile, and evaluate samples at baseline in opposition to varied follow-up intervals to analyze a number of goals. Drs. Dagogo-Jack and Mandal hope to find out the function ceramide and SPLs play in prediabetes danger amongst individuals with regular glucose and a household historical past of kind 2 diabetes, in preventive therapies for kind 2 diabetes, and within the growth of diabetic issues, notably vascular illness. The venture consists of deliberate lipidomics analyses to search out new predictive, prognostic and particular biomarkers for prediabetes, kind 2 diabetes, and vascular issues.
I’m delighted that my colleague, Dr. Mandal, and I have been in a position to pool our experience to launch this collaborative examine. The award from the NIH not solely endorses the scientific deserves of our proposal, but additionally provides a nod to the concept of interdisciplinary collaborative analysis between scientific and fundamental science investigators.”
Dr. Dagogo-Jack, Director, UTHSC Division of Endocrinology, Diabetes and Metabolism
“The scope of the sphingolipid system’s influence on mammalian biology has confirmed to be spectacular, and its roles in human illnesses related to irritation, neovascularization, tumorigenesis, and diabetes is barely starting to be understood,” mentioned Dr. Mandal. “Our deliberate complete evaluation of ceramide regulation throughout the glycemic spectrum from normoglycemia by way of prediabetes to kind 2 diabetes will unravel particular roles of ceramides and different SPLs within the pathogenesis and can present novel SPL-related biomarkers predictive of the event and development diabetes and its issues.”