RUDN College professor and her colleagues from France proved that larger consumption of magnesium and vitamin B6 helps to deal with the results of magnesium deficiency throughout being pregnant and in hormone-related circumstances in girls. Inside 4 weeks, the painful signs turn out to be much less extreme, the standard of life improves, and the dangers of miscarriage are diminished. The outcomes of the research are revealed in Scientific Studies.
Magnesium is concerned in necessary processes within the human physique — from protein synthesis to respiration. The most typical causes of magnesium imbalance are a scarcity of this component within the weight-reduction plan, diabetes, and hypertension. The issue of magnesium deficiency is extra acute for lady, as a result of magnesium is in larger demand throughout being pregnant. The shortage of magnesium additionally results in circumstances related to hormonal problems — endometriosis or polycystic ovary syndrome.
Our research was aimed to evaluate the effectiveness of magnesium-vitamin B6 consumption in reaching normalization of whole serum Mg for sufferers with completely different beginning ranges of deficiency. It was additionally necessary to find out at what Mg degree the painful signs are eradicated, and the sufferers discover adjustments and high quality of life.”
Svetlana Orlova, Physician of Drugs, Head of the Laboratory of Molecular Vitamin, RUDN College
The research concerned 869 pregnant girls, with a median age of 28, and 957 girls with hormone-related circumstances. The median age on this group was larger — 44 years. The members have been residents of various dimension cities in Russia. Laboratory checks confirmed that they’d a decrease degree of magnesium within the serum (lower than the 0.8 mmol per liter). Pregnant girls have skilled signs related to the chance of miscarriage, reminiscent of hypertension and extreme exercise of the uterine muscular tissues. Sufferers within the group with hormone-related circumstances, together with the principle signs have been involved about osteoporosis, premenstrual and menopausal syndromes.
Contributors acquired magnesium and vitamin B6 supplementation in the usual dosage for his or her gender, age, and weight for 4 weeks. Throughout this time, for most girls (73.8% within the group of pregnant girls and 58.9% within the group with hormone-related circumstances) Mg degree elevated to 0.8 mmol / L and better. In a lot of the others, it was within the between 0.66 to 0.8 mmol / L, which is taken into account as a average magnesium deficiency. On the identical time, the whole variety of complaints about painful signs each throughout being pregnant and within the group of girls with hormone-related circumstances decreased by a median of 1.
“Together with the physiological state, we monitored the standard of lifetime of the sufferers. World Well being Group high quality of life questionnaire assessed such points as bodily well being, psychological well being, social relationships, and surroundings. Throughout the research, the scores elevated, and essentially the most noticeable impact was among the many group of girls who reached regular Mg degree ranging from a average deficiency. Thus, we have now proven that the results of a minor magnesium deficiency might be eradicated by receiving supplementation. For extra ssevere deficiency beneath 0.5 mmol / L, therapy should goal the reason for the Mg deficiency”, mentioned Svetlana Orlova, Physician of Drugs, Head of the Laboratory of Molecular Vitamin of RUDN College.
Orlova, S., et al. (2021) Magnesium degree correlation with scientific standing and high quality of life in girls with hormone associated circumstances and being pregnant primarily based on actual world information. Scientific Studies. doi.org/10.1038/s41598-021-85156-y.