In assessing weight acquire throughout menopause, sleep disturbance might play an equally important position to that of estrogen withdrawal, in line with a study introduced nearly at ENDO 2021, the Endocrine Society’s annual assembly.
Though hormonal modifications throughout menopause are sometimes considered the reason for weight acquire, the Mayo Clinic says that it’s as a substitute a mixture of a number of components, together with getting older, lifestyle, and genetics. As one other common symptom throughout menopause, sleep disturbance has independently been associated with weight acquire in girls.
“Attainable mechanisms contributing to this weight acquire could also be modifications in resting power expenditure (REE) and/or nutrient utilization,” hypothesized the examine authors.
Aiming to additional study the position of sleep fragmentation and pharmacologic estradiol (E2) withdrawal on REE and nutrient utilization, researchers recruited 21 wholesome pre-menopausal girls to take part in a 5-night inpatient examine that used an experimental mannequin to simulate sleep disturbance.
Throughout the examine, members had 2 nights of uninterrupted sleep [8 hours (h) total time in bed (TIB)] adopted by 3 nights of interrupted sleep (9-h TIB), wherein they had been woken by an alarm each quarter-hour for a sustained wake time of two minutes.
They then simulated E2 withdrawal by administering leuprolide, a drug that quickly suppresses estrogen to ranges just like menopause, to a subset of 9 sufferers concerned in the identical sleep interruption protocol.
“Research diets consisted of three meals and a snack every day and had been iso-caloric throughout the two visits. REE and nutrient utilization had been assessed within the fasted state through oblique calorimetry and in contrast between E2 states following non-fragmented and fragmented sleep utilizing linear combined fashions,” defined examine authors.
In contrast with a traditional night time of sleep, 3 nights of disturbed sleep in members was proven to change fasting nutrient utilization, as proven by will increase within the respiratory quotient (RQ; +3%; P = .03) and carbohydrate oxidation (+20%; P = .02), in addition to a lower in fats oxidation (-16%; P = .03).
This impact was equally present in these administered leuprolide, even throughout non-fragmented sleep, wherein will increase in RQ (+5%; P = .01) and carbohydrate oxidation (+33%; P = .01), and a lower in fats oxidation (-26%; P = .01) was reported.
“Our findings counsel that not solely estrogen withdrawal but additionally sleep disturbances throughout menopause might contribute to modifications in a girl’s physique that would predispose midlife girls to weight acquire,” stated lead researcher Leilah Grant, PhD, of Brigham and Ladies’s Hospital, in a statement. “Serving to girls sleep higher throughout menopause might due to this fact cut back the possibilities a girl will acquire weight, which in flip will decrease her danger of diabetes and different associated ailments.”
Though nutrient utilization was influenced, no impact of sleep fragmentation or E2 state was reported for REE. Moreover, there was no additive impact of sleep fragmentation on nutrient utilization in these with suppressed estrogen ranges, which researchers counsel might point out a attainable ceiling (RQ and carbohydrate oxidation) and ground (fats oxidation) impact.
Grant LK, Coborn JE, Cohn A, et al. Impact of experimentally induced sleep fragmentation and hypoestrogenism on fasting nutrient utilization in pre-menopausal girls. Introduced nearly at: ENDO 2021; March 20-23, 2021. Summary OR17-4.