With assist from a federal analysis award, Dr. Sarah Grey, affiliate professor of UBC school of medication’s Northern Medical Program, is exploring whether or not magnetic nanoparticles can be utilized as a part of a focused remedy method for sort 2 diabetes.
Working intently with Dr. Urs Häfeli, professor in UBC’s school of pharmaceutical sciences, Dr. Grey will take a look at how magnetic nanoparticles—developed by Dr. Häfeli—can be utilized to ship anti-diabetic medicine. Magnetic nanoparticles are a drug supply device that has been examined for different scientific interventions, comparable to most cancers remedy and medical imaging.
“We’re going to study the usage of this drug-delivery device to focus on anti-diabetic medicine particularly to fats tissue,” mentioned Dr. Grey. “Our aim is to pay attention the medicine in fats the place they will act to enhance metabolism, with out inducing unfavorable negative effects on the physique.”
In line with Dr. Grey, fats, or adipose tissue, performs an vital function in holding metabolism operating easily. In weight problems, this tissue will increase and likewise turns into dysfunctional, resulting in problems, comparable to sort 2 diabetes.
“Whereas there have been medicine used to deal with diabetes that restore adipose tissue operate, they will have detrimental negative effects on cardiovascular and bone well being,” defined Dr. Grey. “We hope to offer proof that can assist secure and efficient therapeutics for folks dwelling with sort 2 diabetes.”
An estimated one third of Canadians have diabetes or prediabetes, with sort 2 diabetes representing 90 per cent of circumstances.
The 2-year $198,743 challenge is funded by the Authorities of Canada’s New Frontiers in Research Fund, by means of the three federal analysis funding businesses (Canadian Institutes of Well being Analysis, the Pure Sciences and Engineering Analysis Council, and the Social Sciences and Humanities Analysis Council).
The federal analysis award will assist experiments carried out in Dr. Grey’s and Dr. Häfeli’s labs, which can deliver collectively their complementary experience in diabetes and drug supply, respectively. The challenge may even present coaching alternatives for graduate college students at UBC and UNBC.
A model of this story was initially printed by UNBC.