Neuropathic ache could probably be decreased with minocycline. These findings from a story evaluate have been printed within the Journal of Ache Analysis.
Researchers from 3 universities in South Korea searched publication databases by January 2021 for articles (N=9) on minocycline and neuropathic pain. The research included on this evaluate included 232 people who got minocycline for his or her ache in randomized scientific trials (n=7) or potential observational research (n=2).
Amongst sufferers with chemotherapy-induced neuropathy, 2 research reported a optimistic impact and 1 research confirmed no impact. One optimistic impact was reported in a research of sufferers (n=22) with breast most cancers receiving minocycline 100 mg twice day by day for 12 weeks. These sufferers reported much less ache and used much less opioid remedy.
One other optimistic impact was present in sufferers (n=19) with non-small cell lung most cancers receiving chemoradiation for six to 7 weeks. These receiving minocycline 100 mg twice day by day had considerably much less ache, fatigue, and shortness of breath. Within the final research, sufferers (n=32) with regionally superior or metastatic colorectal most cancers receiving 100 mg twice day by day for 4 months reported no helpful results.
Sufferers with lumbar ache reported both a optimistic impact or no impact. Sufferers (n=43) with lumbar radicular ache who had obtained 8 days of minocycline on the time of surgical procedure reported no enchancment in ache in contrast with management group individuals when surveyed 3 months later. Sufferers (n=17) who had subacute lumbar radicular ache reported a optimistic impact (1.47-point discount of ache) after 100 mg of minocycline for two weeks. The optimistic impact was decided to be of little scientific significance.
Minocycline didn’t seem like efficient for the remedy of carpal tunnel amongst 43 sufferers who underwent surgical procedure. They obtained 200 mg of the drug 2 hours earlier than surgical procedure after which 100 mg twice day by day for five days.
A discount in ache was reported by sufferers (n=25) with diabetic neuropathy. After 6 weeks of twice-daily 100 mg minocycline, their ache measured on the visible analog scale was decreased from 6.7 to 2.9.
Sufferers (n=11) who took 100 mg minocycline day by day for 3 months for his or her leprotic neuropathy reported a 75% or larger discount of ache, and all however 2 sufferers had practical enchancment as properly.
A research that included sufferers who had numerous etiologies of neuropathic ache discovered that after 4 weeks of escalating minocycline doses from 100 mg to 200 mg, ache was reasonably decreased from 5.6 to five.3.
No research reported adverse unwanted effects.
These information indicated some sufferers with neuropathic ache, particularly these with leprotic neuropathy or diabetic neuropathy, could profit from minocycline remedy with little danger for antagonistic results.
Shin DA, Kim TU, Chang MC. Minocycline for controlling neuropathic pain: a systematic narrative review of studies in humans. J Ache Res. 2021;14:139-145. doi:10.2147/JPR.S292824