Antacids improved blood sugar management in folks with diabetes however had no impact on lowering the danger of diabetes within the normal inhabitants, in line with a brand new meta-analysis revealed within the Endocrine Society’s Journal of Scientific Endocrinology & Metabolism.
Kind 2 diabetes is a world public well being concern affecting virtually 10 p.c of individuals worldwide. Medical doctors might prescribe weight loss program and life-style modifications, diabetes medicines, or insulin to assist folks with diabetes higher handle their blood sugar, however current information factors to widespread over-the-counter antacid medicines as one other means to enhance glucose ranges.
“Our analysis demonstrated that prescribing antacids as an add-on to plain care was superior to plain remedy in reducing hemoglobin A1c (HbA1c) ranges and fasting blood sugar in folks with diabetes,” stated examine creator Carol Chiung-Hui Peng, M.D., of the College of Maryland Medical Middle Midtown Campus in Baltimore, Md.
“For folks with out diabetes, taking antacids didn’t considerably alter their danger of growing the illness,” stated examine creator, Huei-Kai Huang M.D., of the Hualien Tzu Chi Hospital in Hualien, Taiwan.
Varieties of PPIs
There are various names and types of PPIs. Most work equally as effectively. Unintended effects might differ from drug to drug.
- Omeprazole (Prilosec)
- Esomeprazole (Nexium)
- Lansoprazole (Prevacid)
- Rabeprazole (AcipHex)
- Pantoprazole (Protonix)
- Dexlansoprazole (Dexilant)
- Zegerid (omeprazole with sodium bicarbonate)
The researchers carried out a meta-analysis on the results of proton pump inhibitors (PPIs) — a generally used sort of antacid medicine — on blood sugar ranges in folks with diabetes and whether or not these medicines might forestall the brand new onset of diabetes within the normal inhabitants.
The evaluation included seven research (342 members) for glycemic management and 5 research (244, 439 members) for danger of incident diabetes.
The researchers discovered antacids can cut back HbA1c ranges by 0.36% in folks with diabetes and decrease fasting blood sugar by 10 mg/dl based mostly on the outcomes from seven scientific trials. For these with out diabetes, the outcomes of the 5 research confirmed that antacids had no impact on lowering the danger of growing diabetes.
“Individuals with diabetes ought to be conscious that these generally used antacid medicines might enhance their blood sugar management, and suppliers might think about this glucose-lowering impact when prescribing these medicines to their sufferers,” stated examine creator Kashif Munir, M.D., affiliate professor within the division of endocrinology, diabetes, and vitamin on the College of Maryland Faculty of Drugs in Baltimore, Md.
Reference: “Results of Proton Pump Inhibitors on Glycemic Management and Incident Diabetes: A Systematic Assessment and Meta-analysis” by Carol Chiung-Hui Peng, Yu-Kang Tu, Gin Yi Lee, Rachel Huai-En Chang, Yuting Huang, Khulood Bukhari, Yao-Chou Tsai, Yunting Fu, Huei-Kai Huang and Kashif M Munir, 30 June 2021, The Journal of Scientific Endocrinology & Metabolism.
Different authors of the examine embody: Yuting Huang and Khulood Bukhari of the College of Maryland Medical Middle Midtown Campus in Baltimore, Md.; Yu-Kang Tu of the Nationwide Taiwan College and the Taipei Medical College in Taipei, Taiwan; Gin Yi Lee of the Danbury Hospital in Danbury, Conn.; Rachel Huai-En Chang of the Johns Hopkins Bloomberg Faculty of Public Well being in Baltimore, Md.; Yao-Chou Tsai of the Taipei Medical College; Yunting Fu of the College of Maryland in Baltimore, Md.
The manuscript acquired no exterior funding